cisplatine

CONT: Le cis-diamine-dichloro-platinum (sel de platinum) a eu bien du mal à trouver sa place en clinique : sa toxicité rénale a semblé longtemps le disqualifier. Ce handicap, non pas supprimé, mais surmonté par son administration au milieu d'une cure de diurèse, ses indications semblent le rapprocher des agents alkylants.

CONT: Often taken in conjunction with a platinum-based [anticancer] drug called cisplatin, doxorubicin significantly depresses the body's concentration of white blood cells. ... Women with ovarian cancer who receive optimally timed doses of doxorubicin and cisplatin are four times more likely to survive for five years than are women who receive the same drugs in ill-timed doses.

OBS: Utilizado para el tratamiento germinal de testículo, carcinoma de ovario y en otros tumores genitourinarios: cérvix, endometrio, carcinoma de pulmón microcítico y no microcítico, carcinoma de cabeza y cuello, sarcoma de tejidos blandos.